Neurosoc is a society run primarily by postgraduate students in Trinity College Institute of Neuroscience, with a broad membership across campus and a vibrant schedule filled with talks and seminars from leading Irish and international neuroscientists. The society is keen to foster links, both socially and academically, between the clinical and basic scientists at both undergraduate and graduate level in Trinity.

Neurosoc is having an event-packed year: from table quizes, pub nights, and movie screenings, to exciting talks and debates! Why not join in on the fun?

You can sign up to Neurosoc at each event, or drop us an email at neuroscience@csc.tcd.ie. Don't hesitate to contact us if you have any ideas for speakers!



Seminar Series: "The role of fronto-basal ganglia pathways in action control: two effective connectivity studies with ancestral graphs"

Sara Jahfari, Department of Pschology, University of Amsterdam

Venue: Room 3.07(Common Room), 3rd Floor, Lloyd Building

Time: 1pm, Monday the 21st of January 2013


Lecture Abstract:

Regulation of voluntary planned actions is unique in humans, and often described as a symphony between the goal-oriented prefrontal cortex (PFC) and the response gating basal ganglia. Previous findings have shown that the PFC directs the basal ganglia to inhibit planned responses. During this talk I present two recent fMRI studies where effective connectivity was used to examine the interplay between PFC and the basal ganglia, when a prepared response had to be withdrawn. In the first study, we focused on the relative contribution of two important fronto-basal ganglia pathways during response inhibition. Results indicated that response inhibition might be mediated via a fast hyperdirect pathway connecting the right inferior frontal gyrus (rIFG) and the pre-supplementary motor area (preSMA) with the subthalamic nucleus (STN), and the more deliberate indirect pathway between the cortex and caudate. Recent advances have further shown that nodes important for response inhibition within the PFC and basal ganglia can be prepared in advance, when one anticipates the need for control. In the second study, we provide a clear demonstration that the proactive preparation of action plans reduces the need for top-down control of the basal ganglia during response inhibition. Importantly, findings from both studies indicate that both the hyperdirect and the indirect pathway play a crucial role in the process of response inhibition. These results further suggest that top-down control is strongest in an unpredictable environment, where the goal- oriented PFC actively has to update the response gating basal ganglia.



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